366: Allospecific Effector Memory T cells have Decreased Ability to Induce Acute GVHD
نویسندگان
چکیده
منابع مشابه
A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells.
Effector memory T cells (T(EM)) do not cause graft-versus-host disease (GVHD), though why this is has not been elucidated. To compare the fates of alloreactive naive (T(N)) or memory (T(M)) T cells, we developed a model of GVHD in which donor T cells express a transgene-encoded TCR specific for an antigenic peptide that is ubiquitously expressed in the recipient. Small numbers of naive TCR tran...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2008
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2007.12.376